A mother- and father-to-be clash over whether or not to allow Dana to perform in utero surgery to correct a birth defect on their unborn son. Lu must decide whether or not to get involved when a woman she was treating for schizophrenia is charged with murder.

Environmental toxins in a low-income housing unit trigger early menopause in one of its 25-year-old residents. A new mother spirals into depression and runs away from home. Dana meets Nick's mother.

The parents of conjoined twins refuse to have them surgically separated, even though that means they may both die. Lu suspects a leukemia patient may have attempted suicide by starting a fire. Peter is concerned about a patient with a severe rash on her arm and suspects it to be the some kind of virus. Dr. Jackson feels that Rittenhouse needs a good safety & emergency plan and he puts Lana in charge of it.

A pregnant and very ill pro-life politician has her principles put to the ultimate test when the only treatment that will save her life will result in losing her baby. Meanwhile, a patient of Lu's who is trying to pass herself off as a much younger woman is hampered by the inconvenient arrival of menopause.