Lu faces an ethical dilemma about her doctor/patient confidentiality when an abused, pregnant woman appears to be missing. Andy confronts a doctor whose chauvinism may have cost a patient her life.

As a heat wave hits Philadelphia, Andy & the staff will need to get used to its disaster plan to cope with heat wave. Claire a patient of Dr. Campbell is told she will develop Alzheimer's disease within 10 years, she also wants to have a baby.

Andy & tells her kids about Dr. Morton, her kids question why she can't make time for kids. Clare worries that her kids might have the gene PGD (the gene that leads to finding Alzheimer's early.)

A young girl with Down's Syndrome tells Lu she shot a girl to get in a gang. The mother later tells Lu that she had her 16 year old (with Downs Syndrome) confess to the crime to protect her sister who actually committed the crime.

Andy and Lu put their heads together when each of their patients show signs of being poisoned. It appears their exposure to chemicals may turn out to have more to do with where they shop. Lu tries to mediate between an alcoholic and the daughter offering a piece of her liver for transplant.

Dr. Campbell treats a patient for what she believes is alcoholism but she won't admit to her drinking problem. The patient's daughter goes to desperate measure to get her mom to stop drinking. Another of Andy's patients needs to get a kidney transplant but nobody in her family is a match. Tammy's mom then reveals a horrible secret that could save her daughter's life. Meanwhile, Lu, Lana, Peter, and Ben go out on the streets to find out what is threatening the lives of young infants.

A victim of a mysterious accident suffers severe brain damage. Kayla, Andy, and the head neurologist at Rittenhouse, along with his wife, must help him decide whether or not he should have an experimental and potentially life-threatening surgery that would place a chip in his brain. When he concentrated, the chip would put his thoughts on a computer screen. His wife worries that he will agree to do the surgery in the hope that he won't survive it. Peter treats a woman with allergies in a surprising way and has devastating results. After giving a patient of Lu's with a less than reputable job a ride home, Bob is in the doghouse and Lana teachs him a lesson he doesn't need to learn.