Andy tells a famous rock star and a patient to rest and cancel some of her concerts because of fatigue. The rock star invites Lu's young patient who has a terminal disease to spend the day with her. Lu's patient's mother directs a terrible accusation at the rock star. Ben starts a concierge service to keep the clinic open after it faces financial difficulties.

Lu and Andy treat 3 patients that have similar symptoms but seem to have nothing in common. Meanwhile, Andy must meet face-to-face with the drunk driver who killed Milo. Andy is horrified when Jesse befriends him after he gives a speech about the dangers of drunk driving at her school. Meanwhile, Jonas is investigated for insider trading. Later, in a shocking climax, Jesse is in a drunk driving accident.

In a special episode of Strong Medicine, the Rittenhouse Hospital Emergency Medical Services team is introduced. EMTs Kate and Zach are attacked while trying to save a young girl's life, figure out the motive behind it, and reach a dubious resolution. Then, a multiple vehicle accident keeps them and Dr. Vanessa Burke, an African American trauma surgeon and Katie's adoptive sister, busy. A chemical spill threatens the lives of those in the accident and a guilty driver makes an impulsive decision. Meanwhile, a pre-teen in the accident needs a transplant and Katie and Lu search homeless shelters for a match. Even after they find one, they still face some difficulties. Vanessa amputates the legs of a man who begged her to let him die and must convince him that life without legs is still worth living.