Eric enlists the help of a neighbor to stop Matt from smoking, and makes a vain attempt to help Lucy deal with her flowering womanhood.

Shhh! Don't tell anyone, but: Matt and Mary both have mysterious new friends; Simon and his new charge, Happy, could be in the doghouse; and Lucy keeps mum about the object of a crush.

Mary offers to shield Lucy and her "date" from Eric; Matt gets into a scrape while out with a young woman; and Annie goes to Arizona to bring her parents home.

During a difficult labor, Annie asks Dr. Hastings for help. Lucy decides to break up with Jordan because she doesn't feel the same love for him as he feels for her. Simon continues to pray for twin boys. Happy is alone in the house causing some mess and trouble. Simon suddenly decides that he would ask his parent's if he could get his ear pierced. Matt is reluctant and scared about giving blood and also tries to calm everybody's tensions with the arrival of the babies. Lastly, Ruthie is the same as usual in this heart-warming episode; bad-mouthing the twins until they come.

Mary's feelings for Robbie resurface when she inadvertently finds out he has a secret date for Valentine's Day, and the whole family schemes to uncover the mystery woman. Meanwhile, with the exception of Lucy who has a date with Jeremy, the other Camden kids feel deflated when their Valentine's plans fall through and they end up stuck at home celebrating Sam and David's second birthday. Lucy and Jeremy's first date does not go as expected as they both keep on running into Lucy's ex-boyfriends. Although all's well that ends well by the end of the episode for everyone.

When a nasty thunderstorm rolls through the region and threatens to postpone Lucy and Kevin's wedding, everyone scrambles to make it to the church in time. Mary barely catches the last flight in and brings Matt with her. Chandler and Roxanne rush to pick up Ben and his mother who are stranded at the airport in Las Vegas, but tensions run high and a fist fight breaks out; and Matt gives Lucy some very special brotherly advice when she confesses to pre-wedding jitters.

Annie and Ruthie spend the day together to unwind, while Lucy's world becomes complicated by both professional and personal news, and Eric unintentionally shakes up things between Rose and Simon.

Eric suddenly finds himself in heaven, quite literally, when he runs into several people who have gone before him, particularly Annie's late mother. Meanwhile, the family becomes nervous when Eric doesn't come home from work, and Annie tries to hold everyone together. Could he soon be headed to the pearly gates himself?