Lisa sets out to restore the tarnished reputation of Springfield’s first female inventor. To find her invention, she scours an abandoned asylum and a restaurant that caters to men. Bart joins Lisa at the asylum, stealing one of the homicidal patient’s notebooks, and bragging to the boys at school that he wrote the entries himself. This revelation causes Homer and Marge to believe he is a sociopath, which Bart decides to use to his advantage until things go too far.

Mr. Burns hires the Simpsons, except Homer, to be his virtual family; Homer becomes best friends with the girl next door.

All of the fast food restaurants in Springfield go healthy, forcing Homer to turn to the last bastion of greasy food for comfort.

Bart gets in trouble on Grandparents Day at school and is forced to hang out with Skinner's mother as punishment. After spending time with various grandmas in the neighborhood, he learns the benefits of hanging out with the elderly, but eventually recognizes the dangers of taking advantage of them. Meanwhile, Peekimon Get has taken over the town of Springfield.

Mr. Burns will build a doomsday ark after he believes that the end of the world is near when he sees an old Orson Welles show about Nostradamus. Meanwhile, Professor Frink comes up with a new way of testing everyone in Springfield after Burns wants a test to determine who should go on a spaceship with him.

When the Simpsons' flight to Gainesville gets re-routed to New Orleans, Lisa is forced to face her failures, and regain her confidence as a jazz musician. Meanwhile, Bart is intrigued by the voodoo in Louisiana, and Homer is intrigued by the drinking.

When Lisa spots a new best friend from the window of the bus, she gets a taste of what life could be like with a different, more cultured family.

Krusty releases an all-female reboot of “Itchy and Scratchy,” so Bart and his crew of all-male friends decide to boycott the show. After Bart’s friends turn on him for laughing at the reboot, Bart joins a woke group of sixth-grade girls who commit crimes against patriarchy.

When a new neighbor showers him with kindness, Homer thinks he's being tricked into buying a sports car at the dealership where the neighbor works - but the truth turns out to be even more sinister; Lisa neutralizes Nelson after he goes on a bullying spree.

After Bart is turned into an NFT, Marge fights though the blockchain to rescue her son. To track down a gruesome serial killer, Lisa turns to a murderer from her past. An outbreak transforms Springfielders into a plague of lazy, beer-loving oafs.