When a lowlife bookie is found severely beaten, five witnesses identify Ed as his attacker. Unable to provide an alibi, Ed finds himself having to prove his own innocence; and when the victim dies and Ed is arrested on a murder charge, the team have to find out who the real killer is.

The team is at a theatre to watch the rehearsals of a play Ironside has some money invested in, when one of the actors is found dead. Two attempted murders soon follow, and the Chief has his work cut out for him trying both to find the guilty party and to save the play.