In the year 2199, alien beings attack the last of Earth’s space fleet who are protecting a secret mission. Ace pilot Susumu Kodai retrieves an item on Mars that could save the human race, but learns tragic news about his brother.

Mankind finally completes its first interstellar spaceship, the Yamato, which will be sent with a crew to a distant planet. But enemies won’t let them leave Earth so easily.

After their space warp goes awry, the Yamato lands on a floating continent to make repairs. When they discover where the land comes from, the Gamilas attack.

When the Yamato attacks a Gamilan base on Pluto, the crew realizes that they’ll have to take more drastic measures to outsmart their enemies.

Trapped on the Yamato, a Gamilan pilot reveals the truth behind the first contact with earthlings.

An extra-dimensional vessel attacks the Yamato as it approaches the edge of the Milky Way.

Resupply and damage control turns into mutiny when a planet is discovered that’s seemingly a valid alternative to Earth.

Celebrations are in order as the Yamato draws closer to Earth. But with Yuki in critical condition, only a miracle can ensure a happy return home.