In the year 2199, alien beings attack the last of Earth’s space fleet who are protecting a secret mission. Ace pilot Susumu Kodai retrieves an item on Mars that could save the human race, but learns tragic news about his brother.

The Gamilans set their ambush into motion. The two commanders, Domel and Okita, vie for ultimate victory and survival.

With Desler defeated, the Yamato lands on Iscandar in hopes that Queen Starsha will grant them the Cosmo Reverser. Kodai finally uncovers the fate of his brother.