Carter and Lucy are discovered and the staff struggles to save them and go on with normal patient care.

Mark Green is in New York on New Years Eve for cancer surgery. Meanwhile a father and son are involved in a car crash.

A demented patient causes a shootout in the emergency room. After terrorizing people in the ER with a gun, she gets shot by a policeman. She soon dies. Benton later discover her dementia was caused by an aftereffect of his surgery that he and Cleo should have detected. Carter pursues a cute intern.

The ER is flooded with foster care home residents, attacked by a shooter bent on tracking down his son, who , with the help of Dr. Green, was put into the foster care system amid allegations he was being abused by his father.

After Dr. Corday moves out, Dr. Green fights loneliness and pain by immersing himself into his work. He is treating a father in the ER who severely burned himself while experimenting with illegal drugs. Abby fumes when the man who beat her is released and moves back in next door; the returning Jerry clashes with fellow desk jockey Frank.