Carol worries about a Russian girl with AIDS who's brought in and then abandoned by her foster mother. Kayson asks Susan to be his Valentine. Deb accidentally consumes LSD-laced chocolates.

Dr. Hicks berates Benton when he tries to switch shifts to attend his mother's birthday party. A teenage girl, a frequent patient of the ER, is brought in for a drug overdose. Carol decides she wants to adopt Tatiana while Tag isn't so sure. Dr. Ross slugs an abusive father in the lobby. Jen accepts a job offer in Milwaukee despite Mark's offer from Morganstern. Deb and Carter await the arrival of sub-internship applications.

Peter refuses to sleep, despite Hicks' order, in the middle of a 48-hour shift. His lack of sleep catches up with him when he is supposed to be watching his mother. A doctor, who turns out to be a con artist, visits the ER to use it as a model for a new hospital, in the process offering Susan a job. Jenn tells Mark she wants to separate from him. Dr. Ross treats an abused young girl. Carol receives bad news about her attempt to adopt Tatiana. Morganstern informs Mark he's leaving for Boston and will be strongly recommending Mark to his replacement, leaving a surprised Mark uncertain as to his job prospects.