When a drug deal goes bad, two brothers sustain serious injuries and are brought to the ER. Tensions continue between Gates and Sam, coming to a head when Tony is the last to know Alex is about to be released from the hospital. Neela has to tell a young girl with sickle cell anemia that she must have an operation, and the case leads her to consider specializing in pediatric surgery. A feisty patient takes Morris into her confidence. Banfield ponders her choices about expanding her family.

Morris faces a complicated case involving a young girl hit while riding her bicycle. Gates finds it very difficult to let go of his feelings for Sam. Neela becomes quite flustered when Brenner returns from Australia.

A car accident in the ambulance bay injures a woman with a young child and leaves the mother in need of surgery with a significant recovery time. Brenner has difficulty finding a family member to care for the daughter. Gates treats an elderly patient who refuses treatment because he's afraid his condition will prolong an inevitable death. Morris impresses Claudia and her family. Neela tells Brenner about her job offer from North Carolina.

It's Valentine's Day. Dr. John Carter is back at the County. Brenner and Neela are getting closer. Dr. Banfield is having a hard time trying to have a baby. And Puck and mushrooms may not be a good combination.

Carter finds himself struggling with County's new technology and procedures. After becoming frustrated with the in vitro-fertilization, Banfield and her husband discuss adoption as an option. Sam's mother arrives in an altered state of mind.

A camera crew shooting footage for a documentary interviews members of the ER staff. Detective Claudia Diaz is brought in, critically injured with gunshot wounds. Neela laments the lack of communication between her and Brenner. Sam struggles to reconcile with her mother. Carter's condition worsens quite suddenly.

On Neela's last day at County, she has doubts as to whether she is making the right decision.

The ER doctors and nurses help out at Camp Del Corazon, a camp for kids who have had open-heart surgery, working alongside the camp counselor.