When Denny receives bad news about the state of his Alzheimer's, Alan goes before the Massachusetts Supreme Court to plead for access to an experimental drug that could help his condition. Meanwhile, Jerry and Katie try to help a girl get into Harvard after her SAT scores arouse suspicion, and Catherine Piper returns.

Financial problems may force Crane Poole & Schmidt to be put up for sale in the series finale, which also finds Alan petitioning the Supreme Court for Denny's access to a non-FDA approved medicine, and Shirley and Carl planning their wedding.