Yzma’s science class is dissecting frogs, so she turns Kuzco into one so he can be dissected! Instead, he becomes a “hero” known as the Red-Eyed Tree Frog Man.

Kuzco teases a student named Kavo thinking he is just joking around. Kavo, who gets mad about it, decides to beat Kuzco up. Kuzco then hides all over the school and even turns himself into a cat to avoid Kavo.

Kuzco and Pacha's family goes on vacation to the beach. When Kuzco thinks they are taking away his coolness, he starts hanging out with a girl named Yasmine, who just happens to be a young Yzma in disguise.

Yzma's latest scheme to rule the empire includes turning Kuzco into a puma. She plans to slip the puma potion into Kuzco's Meat Mug since that is the only thing he will eat. However, Kronk refuses to tamper with the recipe, so Yzma breaks into Mudka's and steals the recipe. When Kronk finds out, he and Kuzco head for Major Mudka's hut to get back the secret recipe. At the same time, Kronk and Yata try to get Kuzco to eat healthier.

A man arrives in town that claims to be Kuzco's father. Kuzco, who does not remember his father, immediately thinks he is telling the truth and the two becomes inseparable. However, everyone else is suspicious of the man, and it turns out that he might not be who he says he is.