When Sal Monella, a poisonous gangster germ, kidnaps the Mayor with plans to poison Hector, Ozzy and Drix must come to his rescue.

Hector binges on candy, creating a sugar rush that speeds up all the cells and causes the bacteria population to swell. When his parents cut him off sugar, his drop in blood sugar slows all the cells to a crawl. But the bacteria need sugar, so they form an army to raid Hector's sugar reserves. Now Ozzy and Drix, with the help of the Mole, must take on the bacterial army.