A new case arrives at Liz's doorstep, where someone has left a diorama depicting a crime soon to be committed. Meanwhile, Red explores a new business opportunity.

Liz and the Task Force investigate an infamous assassin who has a long history of weaponizing diseases, but has now turned to even more insidious activities. Meanwhile, Red and Dembe travel to Cuba in search of a lead, and Aram considers a new relationship. Elizabeth Bogush guest stars.

Red alerts the FBI to the suspicious death of a scientist specializing in artificial intelligence research. Meanwhile, Francesca Campbell further entangles herself in Red's criminal activities

With the help of the Task Force, Red tracks a gifted art forger who has thwarted his plans to sell stolen pieces. Aram’s love life becomes increasingly complicated. Liz and Ressler confide in each other.

Liz and the Task Force take on a cold case that may have some new victims. Meanwhile, Red tries to help a friend of Dembe who is in danger.