While the Task Force investigates a series of suspicious police shootings, Agent Ressler is distracted by increasing external pressures. With his back up against the wall, Red drafts Tom in executing an elaborate plan to help re-establish his criminal reputation.

Liz and the Task Force hunt for an elusive criminal who will stop at nothing to destroy some of the world's most precious treasures. Meanwhile, a surprise encounter leads a cash-strapped Red toward a new business opportunity, and Tom takes action to investigate the bones in the suitcase.

When Red provides exclusive intel on an international terrorist, it puts Liz and the Task Force on a collision course with a rival unit from the CIA. Meanwhile, Red and Hawkins lay the groundwork for their new business venture, and Tom goes undercover in search of information.

Red and the Task Force place Dembe undercover to infiltrate an international human smuggling organization, but when communication is lost, they must intervene. Meanwhile, Tom's investigation into the suitcase lands him in grave danger.

Tom goes missing and Liz desperately retraces his steps to find him; Red's hunt for the suitcase of bones leads to lives being changed forever.