Red and the Task Force place Dembe undercover to infiltrate an international human smuggling organization, but when communication is lost, they must intervene. Meanwhile, Tom's investigation into the suitcase lands him in grave danger.

Tom goes missing and Liz desperately retraces his steps to find him; Red's hunt for the suitcase of bones leads to lives being changed forever.

When Red directs the Task Force to find a Blacklister who uses his position of power to sell sensitive information, Ressler finds himself at risk of exposure. Meanwhile, Liz plans her next move.

As Liz works with Red to hunt for Tom's killers, she begins to question his motives. The Task Force enlists the help of one arsonist to catch another.

When bodies are discovered in abandoned woods, Red points the Task Force toward The Invisible Hand, a group that targets those whose actions are morally reprehensible yet fully legal. Meanwhile, Red steps in to assist one of his employees, and Liz discovers a major clue about Tom's investigation.

Red assists the Task Force in tracking a mysterious Blacklister who carefully develops airtight alibis for murderous clients. Meanwhile, Liz's reinstatement at the FBI hinges on an evaluation with a psychotherapist.

As Liz continues tracking Tom's killers, Red tries to solve a tax issue in his money laundering. Meanwhile, Aram goes out to the field when the Task Force investigates a viral outbreak.

As Liz investigates new details in a cold case from her early work as an FBI profiler, she explores her darker impulses in therapy with Dr. Fulton. The Task Force takes action to bring down Tom's killers within the legal system, while Red takes a different approach to closing in on Ian Garvey.

When an associate of the Nash Syndicate is murdered, Red sets Liz and the Task Force on the case in order to recover evidence crucial to bringing down Ian Garvey. Meanwhile, Aram considers a step forward in his relationship with Samar.

In an attempt to apply pressure to Ian Garvey, Red and the Task Force head to Paris to track down a prominent heroin supplier for the Nash Syndicate. Distrustful of Red's agenda, Liz takes her own path in going after Garvey.

Liz uses intel from an unexpected source to force Red to uncover the secrets he holds; Red initiates a plan to retrieve the duffel bag of bones.