Nash Bridges, an Inspector in the San Francisco Police Department Special Investigations Unit (SIU), poses as an undercover computer chip buyer to bust a ring that stole $2 million worth of chips. Along with Evan Cortez, his young new partner, they exchange phoney city money with Ferguson, who has the chips; but Ferguson gets away.

As a result of a pension dispute, Joe Dominguez is forced to rejoin the force, and he and Nash track down a heroin dealer.

Nash has to deal with the fact that Joe may have 72 hours to live after being exposed to a deadly virus while Nash & Joe investigate a drug theft from a research lab.

A busload of San Quentin prisoners on their way to court is hi-jacked in downtown San Francisco. Nash has to track down two dangerous escapees, including a paramilitary activist who seeks bitter revenge on Nash.

Nash and the SIU uncover a counterfeitering group where the money is top-of-the-line Supernote quality. Moving in to bust the group, they discover a fake SIU gang impersonating the police. Cooperation becomes tense as suspicions abound over who and what to trust. In the interim, as Nick gets in over his head financially with his horse costs, Nash reluctantly agrees to work with Joe on an off-duty case searching for a Super Bowl ring. However, Nash and Joe soon find themselves impersonating a gay couple as the case develops differently than Nash anticipated.

When the ruthless high school dropouts go on the crime spree, Nash's search for the couple leads him into an underworld of heavy metal rock and satanic worship. As the intensity of the crimes increases, Nash must race against time to stop the desperate duo before they murder all the enemies on their ""grudge list."" ; Stacy and Nash meet Nick's long-lost love from the war years; Joe finds Evan and Cassidy in a compromising situation.

Nash discovers his life savings is gone when his accountant invests in a deal cooked up by "Bombshell" Tamara Van Zant. While trying to remodel the bathroom himself, Joe burns down his house and takes Nash up on his offer to move into Lisa's. Nick decides to take scuba lessons.

Nash and Joe arrive in Las Vegas, and locate assassin Roy McNeer's hotel room. His food is still warm, as Nash and Joe spot McNeer in a casino. Nash and Joe give chase, but are held up by the hotel security guards, as McNeer escapes.

Nash and Joe check into the hotel - Pepe is the concierge. They locate McNeer's girl, Vivienne Reed, and she agrees to tell Joe if McNeer calls her. The truck full of half a billion in laundered cash is hijacked. The two thugs contact Tony B to ransom the truck for $50,000. Tony B and the SIU meet them and get the truck back. Harvey, Evan, Officer Ronnie and Tony B go to Las Vegas with the truck full of money.

Jake Cage shows up in Las Vegas too, with orders from Caitlin and the Mayor's Office to bring back Nash. But Jake agrees to help Nash instead after an altercation.

Nash meets with Ellen Holiday. She fills Nash in on the rest of the DEA investigation. Jimmy Z works for a drug king pin coming in from Shanghai - they have ordered the hit on Police Chief

Nash must track down Rick Bettina, who escapes custody during his parole hearing, and recover the $2.5 million dollars in pension money he stole. Joe plays a modern-day Cyrano when the love affair between Dov and Amy abruptly ends, jeopardizing his remodel.