Greedly and Rigger strip-mine Thailand for rubies.

Sludge and Blight break into government computers and transform all national parks into toxic waste dumps.

Venice's population is relocating due to its pollution and smog affecting the land and structures - but also because of a large mutated group of rats whose bites sicken their victims. The Planeteers arrive and meet a pathologist, Resa, attempting to find a cure for the disease they cause that her young relative Pietre is suffering, and learn through clues that Verminous Skumm is behind it. But it isn't until Ma-Ti is bitten, and badly suffers, that they learn that Skumm is doing it through a substance placed in processed cheese that causes the rats and whoever they attack to become infected by contaminated canal-water. Now they have to find a cure for the worsening patients and stop the rats from terrorizing the populace with the contamination they thrive on.

Sly Sludge and Duke Nukem dump toxic waste in the Amazon rain forest, imperiling Ma-Ti's village. Ma-Ti returns to the village with Planeteers and find it in flames. When they fail to stop the fire, Ma-Ti hunts the culprits alone.

The Planeteers are given a tour of a new "Perfect World," a world with no pollution, clean farming and little potential for environmental backlash. All is created within a computer environment, but Dr. Blight and MAL infect this would-be "paradise" with a shot of viral pollution...