Faith's excitement over having her husband to herself for the weekend is dashed when Fred decides to spend the time trying to win a truck; angry, Faith organizes a drunken girls night out, meets a handsome photographer, and ponders an affair and what might have been; Fred outwits his opponents and wins the truck.

After a despondent woman steps off an eight-story apartment building, the squad finds themselves in a race to transport both the woman's heart and a dying girl to a local hospital in time to save the youngster's life. The suicide hits home for Faith as she comes to grips with her own ongoing medical problems, while Doc expresses concern over the emotional effects this case will have on Kim, despite her constant reassurance that her accident was not an attempt to kill herself.

Even though his co-workers want to nominate him for the "Paramedic of the Year" award, a pensive Doc is disheartened as he considers his unfulfilled life. He later teams with Kim as they try to save a heart-attack victim while fending off a woman wielding a meat cleaver. In addition, Doc tries to minister to a chronic old drunk and a teenaged girl who attempts suicide in her bathtub. Meanwhile, Faith secretly undergoes a procedure to determine if the lump in her breast is cancerous, leaving an unsuspecting Bosco assigned to a nervous rookie cop; Kim reluctantly consults a lawyer about Jimmy's intention to claim custody of Joey.

Doc is up for paramedic of the year and is being followed by a film crew. Doc may have made a medical mistake when treating a patient. Faith recovering from cancer treatment and on the job fails to back up Boscoe while chasing a suspect.

After seeing his young son Joey fall and break his arm in a playground accident, Jimmy fights through a burning apartment building to save a frightened boy of Joey's age. Meanwhile, a guilt-ridden Doc can't stay away from a recuperating teenager, Ryan Buckley, who was accidentally paralyzed while under Doc's care. Taylor is annoyed by a new probationary firefighter, Ken Prescott. Bosco and Yokas search for a drug addict who murdered his girlfriend.

Bosco starts having panic attacks and goes to see a therapist, but it doesn’t work and later he turns to the only person who’ll listen. Carlos is discovering the trials of single parenthood and starts thinking about adoption. Faith is studying for the Sergeant's exam. However, her concerns about Bosco’s mental and emotional health cause her to fail, and this angers Fred, and he storms out of the house. But later, he sees Faith comforting a sobbing and weeping Bosco after Bosco admits that he couldn’t go back to the World Trade Center towers after they fell down.