Bobby comes to the aid of his old friend Paulie after Paulie's sister begs Bobby to help her brother with his drug addiction, but becomes enraged when Paulie breaks into Bobby's mother's house and robs her to support his habit.

After a despondent woman steps off an eight-story apartment building, the squad finds themselves in a race to transport both the woman's heart and a dying girl to a local hospital in time to save the youngster's life. The suicide hits home for Faith as she comes to grips with her own ongoing medical problems, while Doc expresses concern over the emotional effects this case will have on Kim, despite her constant reassurance that her accident was not an attempt to kill herself.

Bosco roams the city looking for Faith, and finally tracks her down just as Faith manages to carry Fred out of the building after rescuing him from the elevator. After they race him to to Mercy, an overwrought Faith lashes out viciously and unfairly, first at Proctor and then at Bosco. As painful as her words are to hear, Bosco realizes the truth be

Sully's stopped drinking, but his poor attitude remains; Carlos gives his two week notice; a blizzard blankets the city and the squads are called in early; an understaffed Doc defies orders and puts Carlos back on the street as the squads are kept busy rescuing victims of the storm; Faith's initial wariness about Emily's new boyfriend Eric turns out to be well-founded when he is brought into Mercy after an overdose of Special K, but doesn't remember where he left Emily after she also got high; Faith, Bosco, Sully, Ty, Doc and Carlos go out to search for Emily, and rush her to Mercy after she's found in critical condition; Faith and Fred blame each other for letting Emily go out with Eric.

The Boscorelli family suffers a tragic loss at the hands of Donald Mann, who blames Bosco, Faith and Maritza for the death of his son in a high-speed chase; the Yokas family heads off in different directions; the Martin family splits apart into separate jail cells for the parents, and a return home for Rebecca to the mother from whom she was stolen as an infant; the paramedic family at the 55 gets a new member, Grace Foster, which makes no one involved very happy.

After a fierce gun battle and some hand-to-hand combat, Mann's gunmen are finally subdued by the members of the 55 in the E.R., but not before Orland is murdered and Bosco is critically injured; after Kim heroically puts herself in the line of fire to save Holly and a little girl, she realizes that her days as a paramedic are over, and that her future lies in being a wife to Jimmy and a mother to their children; Grace and Dr. Fields patch up their differences and come to an understanding about her out-of-protocol field procedures; Maritza uncovers the traitor in their midst, who leads her to Mann; Faith steps over the line to avenge her partner.