Even though his co-workers want to nominate him for the "Paramedic of the Year" award, a pensive Doc is disheartened as he considers his unfulfilled life. He later teams with Kim as they try to save a heart-attack victim while fending off a woman wielding a meat cleaver. In addition, Doc tries to minister to a chronic old drunk and a teenaged girl who attempts suicide in her bathtub. Meanwhile, Faith secretly undergoes a procedure to determine if the lump in her breast is cancerous, leaving an unsuspecting Bosco assigned to a nervous rookie cop; Kim reluctantly consults a lawyer about Jimmy's intention to claim custody of Joey.

Bosco runs from the present and his past when he is wrongly suspected of murdering a sexual assault suspect. As Faith tries to gather evidence to clear him, Bosco turns to his dysfunctional family, including his alcoholic mother, drug-addicted brother and estranged, abusive father. An emotionally rattled Kim virtually kidnaps Joey from Jimmy while Carlos actively solicits Ty to be his new roommate.

Kim and Jimmy are having a custody battle over Joey. Boscoe and Faith are on a call of a possible terrorist threat, that ends up being an explosive event. Alex risks herself to save a little girl and is punished by Doc for it.

Feeling betrayed, Doc angrily confronts his former friend, Jerry Mankowitz, an attorney's investigator who tricked him into confiding vital information about a pending malpractice suit.

The police officers sort through the carnage and count their dead in the wake of a shootout between rival gangs. While Faith tries to interrogate Fyodor Chevchenko, a ruthless Russian mob boss, Sully worries about the severely wounded Ty and regrets causing the incident. Tatiana chastises Sully for hassling her injured son. Faith worries about Gusler, her ineffective, frightened rookie partner and a weary Doc gets some unexpected, good news about his medical malpractice suit.

During the investigation of the gang shootout, the police officers are questioned and presented with evidence that suggests that Ross was killed by friendly fire; Carlos learns that Vangie is dead and that he is the father of the baby her sister leaves at the firehouse; on the first anniversary of Bobby's death, Kim quarrels with Jimmy over her visitation with Joey and confronts a female gang during a call; and Doc is visited by the father of a former patient whose debilitating injury may have been caused by Doc's error during treatment.

Bosco starts having panic attacks and goes to see a therapist, but it doesn’t work and later he turns to the only person who’ll listen. Carlos is discovering the trials of single parenthood and starts thinking about adoption. Faith is studying for the Sergeant's exam. However, her concerns about Bosco’s mental and emotional health cause her to fail, and this angers Fred, and he storms out of the house. But later, he sees Faith comforting a sobbing and weeping Bosco after Bosco admits that he couldn’t go back to the World Trade Center towers after they fell down.