It's Halloween morning and Molly returns home from a long night out to discover a strange woman in her apartment. At work, the guest of honor is missing from her own party. After getting some relieving news from the doctor, Molly goes home to find Florence dressed as a pirate with a tray full of candied apples. But the only trick-or-treater who comes to the door is a mysterious transvestite.

Molly invites Florence and Arthur over for Thanksgiving dinner and, at long last, to meet Nate, but Florence arrives feeling a bit ""under the weather"" and immediately retires to the bedroom. When Nate arrives, Molly is disappointed to see that he is accompanied by his partner, Uribe. What, was supposed to be an intimate family dinner turns to chaos when several other unexpected guests arrive and Molly's oven chooses this night to malfunction.

Over dinner in a restaurant, Molly confronts the father of her baby, who proposes marriage. Molly, caught off guard, accepts and subsequently arranges a dinner meeting between her fiance and Florence, her apprehensive mother. What begins as an awkward evening ends pleasantly for Florence and her soon-to-be Son-in-law, leaving Molly feeling strangely alone.

Molly and Florence go to Ramona's beauty salon to get ready for a night at the opera. Later, in Molly's apartment, her fiance gives her a wedding ring. That evening, Molly grows anxious when her fiance does not pick her up in time for the opera. The eventual knock at Molly's door brings bad news.

Molly goes through tough times as she tries to cope with an unexpected tragedy, as the birth of her baby approaches and as she experiences jitters about her impending motherhood.

Davey and his son Jimmy disagree about their work styles, with Jimmy looking for change and Davey hanging on to tradition. Molly, home from the hospital, spends the first few days alone with her baby. Arthur and Florence drop by Molly's apartment on their way to the Rainbow Room, leaving Molly to ponder the increasing demands of motherhood.

Molly is caught in the middle of her feuding neighbors, Ron and Ramona, who have separated but for economic reasons continue to share an apartment. Florence and Arthur stop by Molly's apartment to check on Fred, who is trying to conduct business over the phone while babysitting. Molly returns home to find Davey depressed, Florence and Arthur about to depart on a trip to an undisclosed location and Fred musing about his blossoming music career ... in Los Angeles.

Molly celebrates her 40th birthday with her best friend, Nina. On her way back home, Molly unexpectedly meets Nick Donatello, the garbage man, who reveals the true nature of their ""chance"" meetings over the years. Ramona and a new date visit Molly's apartment to wish her a happy birthday and run into Ron, who was babysitting. Florence, away with Arthur, checks in with Molly but forgets her birthday. Fred comes over to give Molly a birthday present and say good-bye.