Former Bayside High pupil and current college student Samuel ""Screech"" Powers returns to his alma mater as an administrative assistant to Mr. Belding. A new student from Switzerland, Brian Keller, is attracted to Rachel. Rachel ruins her mom's $700 jacket and the gang helps her come up with a plan to replace it, a plan which makes Screech an unwitting participant.

Megan is running a blood drive and while contributing to it, Screech falls for the pretty nurse Penny Brady. Meanwhile the gang needs to find a chaperone for their camping trip. Brian comes up with a scheme to get Screech to do the job, but first he must get him a date with Nurse Brady.