London 1891. Renowned explorer Sir Malcolm Murray and the strangely beautiful Vanessa Ives recruit American sharp-shooter Ethan Chandler and Dr. Victor Frankenstein to help them search for someone who has been lost.

Vanessa and Sir Malcolm encounter the mysteriously beautiful Dorian Gray at a party. Things take a turn, however, when renowned medium Madame Kali hosts a seance. Meanwhile, Ethan befriends Ms. Brona Croft, a young Irish immigrant.

Dr. Frankenstein is confronted by his past. Vanessa has a vision of Mina, which leads to a strange discovery at the London Zoo.

Vanessa's infatuation with Dorian Gray grows. Professor Van Helsing is hired to work with Dr. Frankenstein. Fenton draws his master to Sir Malcolm's mansion.

Vanessa recalls her past and the events that ultimately lead to Mina's disappearance.

Vanessa's latest vision leads Sir Malcolm, Ethan and Sembene on a search. Professor Van Helsing reveals more details to Dr. Frankenstein about who has taken Mina.

Over the course of four harrowing weeks, Sir Malcolm, Ethan, Dr. Frankenstein and Sembene do everything they can to save Vanessa from what's within her.

After a vision of the Grand Guignol, Vanessa, Sir Malcolm, Ethan, Dr. Frankenstein and Sembene explore an empty theater only to be confronted by their worst nightmares.

As Victor struggles to resurrect Brona, Ethan prepares to leave London and Malcolm discovers that Vanessa is plagued by new visions.

Vanessa meets Caliban for the first time, while Victor begins to train the resurrected Brona in the rudiments of language. Meanwhile, the group turns to Ferdinand for help translating the Verbis Diablo.

Vanessa tells Ethan how she came to harness her abilities thanks to the help of an older witch... and the tragedy that followed.

While Ferdinand helps Malcolm decipher Brother Gregory's writings, Vanessa helps Victor pick a dress for his cousin. Meanwhile, Dorian takes Angelique on a date, and Ethan rescues a young woman from a runaway horse.

After sealing the townhouse against further intrusion, the group goes its separate ways for the moment. Rusk starts asking questions of Ethan, Brona and Victor draw closer, Vanessa teaches Caliban how to dance, and Evelyn launches her next steps in her campaign to seduce Malcolm.

Malcolm learns of his wife's death but isn't as upset as Ethan and Vanessa believe he should be. Meanwhile, Ethan asks Sembene for a favor, and Dorian sends out invitations for Angelique's coming-out ball.

Ethan and Vanessa make their way to the Cut-Wife's cottage to get a weapon against the Nightcomers. Meanwhile, Brona goes out with Dorian.

Malcolm fights off Evelyn's enchantment and goes to confront her. Meanwhile, Brona reveals her true colors to the Creature, and Angelique finds Dorian's portrait.

While Evelyn torments Malcolm, Victor summons Ethan and Vanessa back to London to rescue their friend. Meanwhile, Brona learns Dorian's secret, and Caliban is betrayed.

Vanessa has to use all of her strength to try and defeat the demon.

Ethan, now a prisoner under the watchful eye of Scotland Yard Inspector Rusk, is on a train speeding through the desert of the American West. Meanwhile, Sir Malcolm is confronted by a mysterious Native American man in Zanzibar. Back in London, Dr. Frankenstein seeks out his old friend Dr. Jekyll and Vanessa seeks the help of Dr. Seward to battle a new evil.

Lily and Dorian pay a visit to a most unusual show, and Vanessa invites Sweet to a different show. Rusk sets out to track down Ethan and make sure that he hangs, and Henry demonstrates the efficacy of his potion for Victor.

Vanessa asks Seward to hypnotically regress her after learning that she met the Master sometime in the past. Rusk learns that Ethan has a new ally. Caliban finds his wife and child. Lily and Dorian have Justine pledge her service to them.

Through hypnosis, Vanessa relives what happened to her in the Banning Institute, including the man who befriended her... and the spirits who tormented her.

Hecate and Ethan try to survive in the desert wasteland, as thirst and their unrelenting pursuers take their toll. Meanwhile, Victor and Henry continue with their work in Bedlam.

Vanessa turns to old friend Ferdinand Lyle for help, who introduces her to a new ally. Meanwhile, Lily, Dorian and Justine put their plan in motion; and Ethan, Sir Malcolm and Hecate arrive at Jarod Talbot's ranch.

Kaetenay has a vision of impending doom. Frankenstein and Jekyll get help from an unlikely foe. The Creature finally gains courage. Vanessa learns an awful truth.

Ethan, Sir Malcolm and Kaetenay return to London, where Ethan searches for Dr. Frankenstein. Dr. Seward discovers Renfield's secret. Lily reveals a heartbreaking story from Brona Croft's past.

Season finale. Ethan learns the shocking truth about Kaetenay. Dr. Seward uses hypnosis on Renfield. Meanwhile, The Creature must make a moral decision as Sir Malcolm, Ethan, Kaetenay, Dr. Seward and Catriona battle to save Vanessa.