Hecate and Ethan try to survive in the desert wasteland, as thirst and their unrelenting pursuers take their toll. Meanwhile, Victor and Henry continue with their work in Bedlam.

Vanessa turns to old friend Ferdinand Lyle for help, who introduces her to a new ally. Meanwhile, Lily, Dorian and Justine put their plan in motion; and Ethan, Sir Malcolm and Hecate arrive at Jarod Talbot's ranch.

Kaetenay has a vision of impending doom. Frankenstein and Jekyll get help from an unlikely foe. The Creature finally gains courage. Vanessa learns an awful truth.

Season finale. Ethan learns the shocking truth about Kaetenay. Dr. Seward uses hypnosis on Renfield. Meanwhile, The Creature must make a moral decision as Sir Malcolm, Ethan, Kaetenay, Dr. Seward and Catriona battle to save Vanessa.