London 1891. Renowned explorer Sir Malcolm Murray and the strangely beautiful Vanessa Ives recruit American sharp-shooter Ethan Chandler and Dr. Victor Frankenstein to help them search for someone who has been lost.

Vanessa and Sir Malcolm encounter the mysteriously beautiful Dorian Gray at a party. Things take a turn, however, when renowned medium Madame Kali hosts a seance. Meanwhile, Ethan befriends Ms. Brona Croft, a young Irish immigrant.

Vanessa's infatuation with Dorian Gray grows. Professor Van Helsing is hired to work with Dr. Frankenstein. Fenton draws his master to Sir Malcolm's mansion.

Vanessa's latest vision leads Sir Malcolm, Ethan and Sembene on a search. Professor Van Helsing reveals more details to Dr. Frankenstein about who has taken Mina.

After a vision of the Grand Guignol, Vanessa, Sir Malcolm, Ethan, Dr. Frankenstein and Sembene explore an empty theater only to be confronted by their worst nightmares.

While Ferdinand helps Malcolm decipher Brother Gregory's writings, Vanessa helps Victor pick a dress for his cousin. Meanwhile, Dorian takes Angelique on a date, and Ethan rescues a young woman from a runaway horse.

Ethan and Vanessa make their way to the Cut-Wife's cottage to get a weapon against the Nightcomers. Meanwhile, Brona goes out with Dorian.

While Evelyn torments Malcolm, Victor summons Ethan and Vanessa back to London to rescue their friend. Meanwhile, Brona learns Dorian's secret, and Caliban is betrayed.