Ellen welcomes Vince Vaughn for his first appearance, where he discusses quitting smoking and has a dance-off with the audience. She also surprises a 10-year-old cancer survivor, while Missy Elliott talks about her new reality show and bold fashion choices.

Vince Vaughn and Owen Wilson join Ellen to chat about their movie “Wedding Crashers,” quitting smoking, and party-crashing adventures before taking their rivalry to the track in a thrilling go-kart race. Plus, Owen hilariously embraces his “twin” connection with Ellen!

VINCE VAUGHN lands in ELLEN's guest chair and chats about his hit film, "The Break-Up," and his relationship with JENNIFER ANISTON. And, America voted and made TAYLOR HICKS your "American Idol," now the lead member of the "Soul Patrol" performs a song from his upcoming CD. Plus, one of Ellen's favorite bands, LIVE, performs their hit "Mystery."

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