James Denton chats about “Desperate Housewives,” guest stars, and his workout routine — plus, he takes his pants off for charity! Meanwhile, Rachel Weisz discusses her award-winning role in “The Constant Gardener” and shares behind-the-scenes stories.

Meryl Streep chats about her record-breaking Oscar nominations and shows off her accent skills, memory expert Jim Karol stuns with mind-blowing tricks, and Jason Lee stops by to discuss his hit show "My Name Is Earl!"