After decades apart, Jamie and Claire finally reunite and rekindle their emotional and physical bonds. But Jamie's new business dealings jeopardize the couples' hopes for a simple life together.

Claire follows her conscience as a surgeon, even though it could put her and Jamie's lives at risk. At the same time, Jamie attempts to evade the reach of the Crown as it representative closes in on his illegal dealings.

Claire and Jamie leave Scotland, sailing to the West Indies on an urgent quest. But when the superstitious crew looks for someone to blame after a string of bad luck, rescue comes from an unlikely source.

Claire races to discover the source of an epidemic aboard a disease-stricken ship before hundreds of sailors die. And as Jamie locks horns with Captain Raines, Fergus finds himself torn between loyalty and love.

After making a leap of faith, Claire washes up on an island where survival is her only option. Navigating treacherous waters crippled the Artemis, so Jamie devises a joyful moment for his crew in the midst of setbacks.

The Artemis finally reaches Jamaica bringing Jamie and Claire much closer to their goal. During a ball on the island, the Frasers encounter old allies, as well as former adversaries who threaten to derail their mission.

Claire plays a game of cat and mouse with an old adversary as she searches for young Ian. The Frasers race through the jungles of Jamaica to prevent the unthinkable.