Intelligence investigates a doctor who gave his patients lethal doses of chemotherapy. Roman fights a wrongful shooting investigation.

The crossover starts on Chicago Fire S04E10 The Beating Heart (I) and Chicago Med S01E05 Malignant (II).

When Burgess and Lindsay respond to a call about a stabbing, the assailant turns out to be a kidnapping victim escaping her captor; Ruzek accuses Roman of having feelings for Burgess.

Responding to a call about a suspicious duffel bag at the Chicago Lakefront, Voight is horrified to discover that the bag contains the frigid and unmoving body of a newborn baby. Meanwhile, Voight is surprised to hear that his son is in town and Burgess and Roman grow closer.

After zeroing in on the suspect responsible for the bioterrorism that’s gripping Chicago, the PD prepares to undertake their biggest manhunt yet. Upton is torn between helping track down the perp and providing emotional support to the scared young girl that needs her. Voight fears his team is being sent on a wild goose chase.

The crossover starts on Chicago Fire S08E04 Infection (I) and Chicago Med S05E04 Infection, Part II (II).