After a doctor is found dead at a golf course, the CBI team searches for a killer amongst a hospital's staff and patients. Meanwhile, when LaRoche is placed in charge of the CBI, his first act of business is to name Cho the new team leader.

When the CBI team travels to a resort town to find out who murdered a police chief, Lisbon crosses paths with her brother Tommy, now a bounty hunter, who's tracking a bail jumper.