Meet Ash Ketchum, a 10-year-old boy full of imagination, confidence, and dreams that are almost too big for his village of Pallet Town—plus the desire to become a Pokémon Master!

On the way to Vermillion City, Ash meets AJ, a Gym Leader at an unsanctioned Gym who has 98 wins and zero losses. They battle, and Ash is surprised that AJ's Ground-type Sandshrew can easily beat his Flying-type Pokémon.

Ash and his friends walk along a path and fall into a hole dug by a batch of mischievous Squirtle. Ash climbs out and tries to battle them, but they scatter when Officer Jenny arrives.

Ash and his friends have finally arrived in Porta Vista, a beach-side tourist town. After destroying an old man's ship, they must help in the old man's business. To attempt to pay the man back faster, Misty enters a beauty contest, only to discover she is competing against Jessie and James.

In search of a ghost Pokémon, Ash heads immediately for a tower in Lavender Town where they are said to dwell.

In the outskirts of Fuchsia City, our heroes come across Hitmonchan, a fighter-Pokémon. With little thought, Ash attempts to capture it, but he and Pikachu are badly defeated.

Ash and his friends get challenged by Team Rocket in seeing who can capture the most Pokémon within the Safari Zone, with Ash catching a whole herd of Tauros. As soon as Ash and his friends head out Pokémon hunting, Team Rocket manages to get the drop on the game warden (Mr. Kaiza) and forces him into giving up the location on where Dratini is (the Dragon Valley). In the end, Ash, his friends, Team Rocket, and Kaiza end up seeing the legendary Dratini and Dragonair, with the heroes saving the day.

Team Rocket never let up with their constant interception, but today something seems strange. The coin on Meowth's forehead is blinking red, indicating overheating.

As our heroes sleep peacefully, Pikachu begins experiencing an unusual sensation. As though it were choking on something, Pikachu's expression grows steadily more and more pained.

Ash enrolls Pikachu in a training school for police Growlithe, but the course is tougher than he imagined, for himself and for Pikachu!

Ash, Brock and Misty get sidetracked on their way to Viridian City when all of their belongings mysteriously disappear.

Back in Pallet Town, Ash finds Gary, already there, waiting to partake in the Pokémon League. Always having a bitter rivalry with Gary, Professor Oak tells them both the meaning of Pokémon. Meanwhile, Team Rocket is trying to get inside the lab to steal the Pokémon.

Ash and his friends go to Hollywood (although only a small nearby town) to see the premiere of the movie their Pokémon were cast in. Team Rocket follows them to find out that Meowth has history in this town; It is here where he was a member of a gang of street Meowths led by the Persian. He learned to speak and walk upright to win the heart of a female Meowth who was abandoned by her owner. Upon returning, he challenges Persian who was once his mentor for the female Meowth he thought he lost years before.

Ash, Brock, and Misty prepare for their long journey to Valencia Island to bring back a mysterious Poké Ball for Professor Oak. After discovering that the trip will take a month to get there, Ash manages to win a free blimp ride so it will take only a day! Once on board, they realize the blimp is being powered by Team Rocket! And things only get worse from there!