Professor Utonium falls head-over-heels in love for the lovely Ima Goodlady. Unfortunately, she's really the sinister Sedusa, out to keep the Girls grounded for the first time ever while she commits crimes around Townsville, such as making off with the Mayor's jewels.

The citizens of Townsville loves The Powerpuff Girls and its annoying Him, so Him turns everyone's love for the Powerpuff Girls into hate.

The Mayor creates a commotion in Townsville about being re-elected as Mayor again, but he wakes up Fuzzy Lumpkins who get's annoyed. The people like Fuzzy and vote him Mayor.

Nerd boy Lenny Baxter has every single Powerpuff merchandise on the entire planet and now he decides to collect The Powerpuff Girls.

Putting everyone in the world asleep can be a hard job so to make it easier Sandman puts the world to sleep forever.

Bubbles gets hit on the head by Mojo and gets amnesia.

The Powerpuff Girls save the day before and after their bedtime, and by the time they're at school they always sleep in class. Annoyed by this Ms. Keane talks to the Professor and he gives them a curfew.

Ms. Bellum seduces the Mayor to get some time off, but when something seems a miss the Powerpuff Girls investigate the situation.

Blossom and Buttercup have an argument thinking that brains or brawn is the best way to destroy a monster.

The Mayor gets sick and tired of the Powerpuff Girls saving the day so he decides to save the day by himself.

The Gang Green Gang raids a mini mart eating all types of foods. When the Powerpuff Girls arrive they use their heat vision which causes a chain reaction which gives the Gang Green Gang super powers.

Him has given the girls a set of nine riddles to solve in a time limit. The various tasks test both the girls' physical and mental faculties. However, if they fail to complete them all on time, Him promises them that "the Professor will pay".

In this musical, the girls are outmatched by Townsville's villains. They turn to Gnomey to bring peace to Townsville in exchange for their powers, but, when the city falls under the rule of Communism, it's up to the girls to stop him.

After the Professor lies to the girls to avoid spending time with them a little white lie monster develops.

A medium named Madame Argentina, and her side-kick, Fred the duck (he really is a duck) attempt to steal money from Townsville's citizens by offering to contact a dead relative for them.