The Ganggreen Gang gets hold of the Mayor's hotline to the Powerpuff Girls and makes prank calls, sending the Girls on a wild goose chase all over town. However, when it's the notorious villain's Mojo Jojo, Fuzzy, and Him that the gang disturbs, they learn the price of making prank calls.

The citizens of Townsville loves The Powerpuff Girls and its annoying Him, so Him turns everyone's love for the Powerpuff Girls into hate.

Buttercup teases paste-eating classmate Elmer. When a fly with atomic chemicals enters the paste, Elmer turns into a destructive Paste Monster. Buttercup has to get out of a sticky situation by doing something against her tough nature—apologizing.

On a very hot and humid day Blossom discovers that she has ice powers.

The Powerpuff Girls try to stop the villains of Townsville from obtaining the Key to the World, which actually gives its possessor the right to rule the world.