Gordon and Bullock sift through evidence from the murder at Lee and Mario's engagement party; Ivy discloses her identity to Selina and Bruce.

On the run from Gordon and Bullock, Dwight tries to revive Jerome, in turn, activates his acolytes around Gotham City. Meanwhile, Selina's mom's intentions in Gotham are revealed, and the power play between Penguin and Nygma escalates as Barbara's plans are set in place.

With the deadly virus spreading throughout the city, the search for the antidote continues, as Fish Mooney, The Riddler and Penguin reveal plans of their own. Bruce meets Ra's al Ghul and completes his last task in order to fulfill his destiny, but realizes he can't let go of his past. Meanwhile, Gordon tries to win back Lee, and past alliances within Gotham City are broken, while new alliances are formed.