While Barry and Iris deal with the heartbreaking loss of their daughter, Nora, the team faces their greatest threat yet — one that threatens to destroy all of Central City. Meanwhile, Killer Frost has a brush with death that results in an unexpected new dynamic that will change her relationship with Caitlin forever.

Faced with the news of his impending death, Barry's resiliency suffers as he struggles to fight fate. Meanwhile, Cecile's career as a D.A. conflicts with her identity when she crosses paths with a villainous meta-human.

Knowing that Crisis is only weeks away, Barry prepares a member of Team Flash for life without him while hunting a terrifying meta-human with an unquenchable thirst. Meanwhile, Ralph uncovers a family secret.

Barry's efforts to prepare Cisco for Crisis are derailed when Cisco schemes to save Barry's life instead. Meanwhile, Ramsey Rosso uses his deadly new abilities to save his own life, while sacrificing his humanity in the process.

Cisco's faith in his ability to fill Barry's shoes as Team Leader is upended when he learns of a shocking murder. Meanwhile, Killer Frost trusts no one except herself to hunt down the dangerous Ramsey Rosso.

Barry turns his attention to prepping Elongated Man for life after Crisis and without The Flash, but Ralph ultimately teaches Barry a lesson. Meanwhile, Cecile faces her own moment of self-discovery while helping a recuperated Chester P. Runk reclaim his identity.

As Barry Allen stands on the threshold of his impending death in Crisis, his convictions are tested when the monstrous Dr. Ramsey Rosso infects The Flash with a mysterious, hallucinogenic contagion. Meanwhile, reporter Iris West-Allen uncovers a vast conspiracy.

With The Flash freshly infected by the monstrous Bloodwork, Iris and Cisco battle to help Barry take control of himself before he’s lost forever to Ramsey’s influence. Meanwhile, the rest of Team Flash fight to reclaim control of Central City from Bloodwork’s growing army.

After recent events, Barry takes a closer look at his life with Iris. Eva makes a bold move.

Team Flash throws a surprise birthday party for Barry, but things go terribly awry when Ramsey Rosso crashes the festivities.