In New Orleans, Constantine's unusual knowledge of a string of crimes gets him into trouble with Detective Jim Corrigan. He must form an unholy alliance with Papa Midnite when a voodoo ritual to help people communicate with their dead loved ones takes a deadly turn.

When John heads to a local hospital to investigate a mysterious attack, he enlists an unwitting Manny to help him. Meanwhile, a health scare causes Zed to question the source of her visions.