The crew members arrive at the Guantanamo Bay military base to collect food, fuel and medical supplies. When they come under attack by escaped Gitmo prisoners, they team up with a gruff private contractor to push back against the offensive.

The crew faces a new foe targeting Rachel and her research, leading Chandler to engage in a series of dangerous strategic maneuvers.

After picking up a distress call near Jamaica, Chandler and a small team stage a rescue attempt. But a surprise attack leave Chandler and Tex stranded at sea. Slattery and the crew search desperately to find their lost at sea Captain and his comrade, hoping to do so before their enemies beat them to it.

With Chandler and Tex caught in a dangerous situation, Slattery has to step into the role as commanding officer. Torn between a mission with the fate of the world at stake and a Captain (and friend) in danger, Slattery has to find a way to get his people back without losing the most important asset: the vaccine prototype.