Chandler's leadership is put to the test when the ship's propulsion system is in danger of breaking down, the crew becomes overworked and exhausted, and Dr. Scott could potentially lose all of her research on the virus.

After returning from the horrors of Nicaragua, panic begins to spread throughout the ship when Lt. Danny Green comes down with a mysterious illness that could be the virus. Losing faith in Rachel and her failing vaccine trials, Chandler now has to deal with a restive crew. If he fails to keep the crew together, the whole mission is in jeopardy.

After picking up a distress call near Jamaica, Chandler and a small team stage a rescue attempt. But a surprise attack leave Chandler and Tex stranded at sea. Slattery and the crew search desperately to find their lost at sea Captain and his comrade, hoping to do so before their enemies beat them to it.