Annalise helps Paula Murphy, a suburban soccer mom, get released from jail after she was arrested for a misdemeanor, but just as she’s about to walk free, she’s arrested again by the FBI in connection for felony murder. Annalise and her students are tasked with proving her innocence which will depend on the testimony from another suspect in the case. Meanwhile, the Middleton University president asks Annalise to represent Griffin O’ Reilly, the star quarterback who has also been linked to Lila’s disappearance but she’s unable to make a decision until she knows that Sam wasn’t involved in the case. In flash forwards, more clues are revealed and we discover someone else was also there besides the students during the night of the murder.

School is back in session after the holiday break and the entire university is talking about Annalise's missing husband. The Keating Five continue to be questioned by the police and we find out exactly how they've been dealing with the guilt of killing Sam. Sam's sister Hannah shows up and has started her own investigation of what happened to Sam.