The heroes are reunited, but soon find themselves navigating an unexpected tragedy as they engage in fierce fighting with both zombies and bounty hunters who are eager to capture Murphy, dead or alive. Meanwhile, Vasquez makes a strategic decision.

While crossing the Mississippi, the team splits up after a boating accident; 10K is drawn into a scam; Escorpion sentences 10K, Sketchy and Skeezy to death.

The team meets La Reina, Queen of the Zeros, after being captured. Dr. Kurian is ready for human trials on his Z-vaccine at the Zero compound.

It's discovered that the Z-vaccine doesn't work. Vasquez gets caught trying to kill Escorpion; Murphy uses mental manipulation to help Roberta.

The team reaches the mobile lab, which turns out to be a submarine. Murphy says goodbye.