When Elizabeth faces the daunting task of negotiating with Iran over their escalating nuclear program, she is determined to deal with the situation in a peaceful manner, despite the President's position of using military action. Meanwhile, Jason has new admiration for his father when he interviews him for a school report.

Elizabeth pushes for the prosecution of a Bahraini diplomat after he is caught holding a maid hostage in his home. Also, Henry's father comes to visit.

Elizabeth secretly travels to Iran in an attempt to prevent a coup that could impact President Dalton’s administration. Also, she brings her staff up to speed on the investigation into Marsh’s death.

While Elizabeth seeks a diplomatic solution to a doomsday cult in Bolivia, a congressman attempting to negotiate with its leader is taken hostage. Meanwhile, Elizabeth and Henry meet Stevie’s much older boyfriend.

As Elizabeth holds peace talks between the prime ministers of India and Pakistan, a mysterious plane crash tied to both countries causes the three parties to reevaluate the deal. Also, in an attempt to help the NSA locate the terrorist Jibral Disah, Henry approaches a former teacher of one of Disah’s wives for information, and Elizabeth withstands a grueling interview with Jane Pauley.

When President Dalton gets word that the world’s most wanted terrorist, Jibral Disah, is hiding in Islamabad, he sends the “Murphy Station” – Henry, Jane and Jose – on a dangerous mission to eliminate the threat. Also, Elizabeth and Henry go to couples therapy.

The United States debates enacting a “render safe” mission to secure nuclear weapons that belong to the Pakistani government before it collapses, while the Murphy Station pursues the terrorist Jibral Disah.

With Algeria on the brink of a civil war, Elizabeth delicately negotiates a regime change, but her plans go awry when Roy Curtis, the trusted U.S. Ambassador to Algeria, dies unexpectedly. Also, Henry fights to save religious antiquities in Algeria when he discovers they are being destroyed by Hizb al-Shahid.

After U.S. environmental activists protesting China’s damage of a South China Sea reef are arrested for spying, Elizabeth finds herself in a stalemate with the Chinese foreign minister as she lobbies for their release.

After Venezuela’s president and his immediate successors are killed in a devastating earthquake, Elizabeth works to stop a power grab by the late president’s son, as well as secure the release of the international aid team he arrested.

As the U.N. Security Council considers reinstating sanctions against Iran for its suspected nuclear activities, Elizabeth tries to stop Israel from taking matters into its own hands when it threatens military action against the Iranians.

When a possible Israel-Iran war threatens the House’s imminent vote on the U.S. presidential election, Elizabeth attempts to bring the two reluctant countries to the negotiation table in an effort to broker a peace between them. Also, Russell’s life hangs in the balance after a heart attack.

Henry disagrees with the President and Elizabeth when they refuse to negotiate with terrorists for the release of an American CIA agent who was captured by the Taliban in Afghanistan. Also, Elizabeth tries to be supportive of Stevie who is going through a difficult time.