The President’s plane is declared missing and Elizabeth is thrust into a situation of power she never imagined possible. Also, Henry butts heads with his new Defense Intelligence Agency handler, Jane Fellows, when he’s asked to recruit one of his Russian students for the NSA.

Elizabeth takes advice from former Secretary of State Madeleine Albright and ignores President Dalton's recommendation on how to negotiate the safe return of a Sate Department employee who was kidnapped in Afghanistan. Meanwhile, Henry is having trouble persuading a student to spy for the U.S. government.

Elizabeth and President Dalton’s administration are met with hostility while trying to deal with the Russian government. Also, Dmitri is kidnapped and interrogated about being a Russian spy.

Elizabeth finds herself pushed out of the President's inner circle after she disagrees with his response to the growing tension with Russia. Also, when incriminating photos of Stevie and Harrison surface, Elizabeth and Henry must deal with the aftermath and try to protect their daughter from the media.

In the wake of President Ostrov’s death, Elizabeth and President Dalton fear a power grab within the Russian government. Also, the government’s Cybersecurity Coordinator Oliver Shaw works to identify the hacker who interfered with the communication system on Air Force One, and Jay devises a plan to fight Russian propaganda.

With the support of President Dalton, Elizabeth attempts to get the Senate's support for a history-making effort to lift the Cuban trade embargo. Also, Henry and Alison bond while touring Havana together.

As tensions rise with Russia, Elizabeth, Russell and Mike B. hatch a plan to oust National Security Advisor Craig Sterling without tarnishing President Dalton with a scandal. Director of National Intelligence Ephraim Ware identifies who hacked Air Force One.