As Elizabeth holds peace talks between the prime ministers of India and Pakistan, a mysterious plane crash tied to both countries causes the three parties to reevaluate the deal. Also, in an attempt to help the NSA locate the terrorist Jibral Disah, Henry approaches a former teacher of one of Disah’s wives for information, and Elizabeth withstands a grueling interview with Jane Pauley.

Elizabeth learns that a member of the inner circle of the terrorist group Boko Haram has fallen ill with a deadly virus and, by leveraging his weakness, she formulates a plan to get them to release a group of schoolgirls they are holding captive. Also, Henry gets new information on the whereabouts of Jibral Disah that leads them closer to pinpointing his location.

The United States debates enacting a “render safe” mission to secure nuclear weapons that belong to the Pakistani government before it collapses, while the Murphy Station pursues the terrorist Jibral Disah.

When an imminent U.S.-France state dinner is jeopardized after a CIA operative is captured by French intelligence, Elizabeth must negotiate the operative’s release while keeping the event on track.

When Elizabeth discovers that a terrorist bombing at an Illinois coffee shop was funded by someone with close ties to the Saudi government, she makes a bold move after the Saudi ambassador refuses to bring the man to justice. Also, Matt refuses to issue a statement when news breaks that he and the bomber are linked to the same mosque, and Henry reaches out to Dmitri when he hears he’s having trouble adjusting to his new life in Phoenix.

When a possible Israel-Iran war threatens the House’s imminent vote on the U.S. presidential election, Elizabeth attempts to bring the two reluctant countries to the negotiation table in an effort to broker a peace between them. Also, Russell’s life hangs in the balance after a heart attack.

When the upcoming marriage of two star-crossed lovers from Colombia is in jeopardy, Elizabeth works to reunite the son of the Colombian president and the daughter of the rebel leader, whose union is at the heart of an important peace deal after years of civil war. Also, Henry prepares to send his operative undercover, Jay deals with his tenuous marital situation, and Daisy makes a shocking discovery regarding Kevin.

Elizabeth is shocked when the Philippines' unconventional new president, Datu Andrada, makes a pass at her during their meeting to discuss his refusal to participate in an Asia-Pacific territory treaty. Also, Elizabeth asks Jay to look into Kevin Park's CIA connections, and Henry fears for his operative who is embedded in the religious cult when he goes radio silent.

Elizabeth’s landmark global climate treaty with more than 200 countries is jeopardized when China threatens to back out due to her meeting with an ailing Dalai Lama. Also, Henry worries about his undercover operative’s safety, and Jay is surprised when Abby serves him with a custody agreement for their daughter.

When a computer sting uncovers the possible mole in the CIA arms smuggling ring, Elizabeth’s questioning of the suspect makes her think that a larger, more dangerous force is behind the operation. Also, Henry worries that the doomsday cult is drugging his embedded operative, and Elizabeth and her State Department staff come up with an unorthodox approach to solving black rhino poaching in Namibia.

When warring rebel groups threaten Elizabeth’s Somalian food relief efforts and kidnap an American aide there, she reluctantly considers asking a notorious Russian arms dealer for help. Also, Henry is blindsided when he is taken off the VFF doomsday cult case, and Alison and Stevie await their college acceptances.

As Elizabeth and President Dalton head to Rome for the G20 Conference, she is concerned for Henry’s safety when he is sent to Israel to intercept the doomsday cult’s bio-weapon before it is deployed. Also, Blake reveals a personal secret to his former colleagues that he meets at the conference, and Elizabeth goes behind Stevie’s back to ask Russell to get her off Harvard Law School’s waiting list.

Elizabeth heads to Brussels to seek NATO’s support against Russia when it threatens to invade Bulgaria, but when France refuses to cooperate, it could threaten the alliance’s very existence. Also, Henry’s new government role has him dive into the Russia issue and turn to his former operative, Dmitri Petrov for help, and as Nadine and Mike B’s relationship heats up, Elizabeth finds out information about her old friend that makes her question his loyalties.

Secretary of State McCord and her staff work with the Mexican government to extradite a Mexican cartel leader to a U.S. prison in an effort to diminish the opioid crisis. But after he escapes during transport and a journalist who secured a gloating interview with him while on the lam is murdered, Elizabeth’s urgency to find the leader escalates.

Secretary of State McCord reluctantly agrees to host a holiday party in the hopes of persuading senators in attendance to pass a treaty that requires countries to destroy landmines. Also, Henry tries to find evidence that the Senate Majority Leader exchanged information with the Russians.

When Vice President Hurst feels threatened that Secretary of State McCord is vying to be the next president, she attempts to set Elizabeth up for failure by promising that Americans will continue to be able to adopt Russian orphans, despite the potential ban by Russia’s president. Also, Elizabeth and Henry find out Stevie is dating Dmitri after he is followed by a Russian assassin.