When Elizabeth and her staff fly to Africa to offer development aid to the continent, they are caught by surprise when the Chinese arrive there first, ready to outmaneuver the U.S. with competing offers of aid. Also, when turbulence on their plane ride to Africa leaves Daisy unnerved, she and Susan Thompson go on a welcome tour of Africa, admiring the beauty of the continent. And, the FBI asks Henry to help investigate a Christian cult member who may have helped build the bomb used in the Illinois coffee shop attack.

When an influential rabbi organizing a symbolic Iran/Israel soccer game is killed, Elizabeth and Jay’s peace treaty plans for the two countries are jeopardized. Also, Elizabeth’s name is floated for a Nobel Peace Prize. Jay’s tireless work on the Iran/Israel peace deal strains his marriage. Daisy makes a connection with new work colleague, Kevin Park.

When the upcoming marriage of two star-crossed lovers from Colombia is in jeopardy, Elizabeth works to reunite the son of the Colombian president and the daughter of the rebel leader, whose union is at the heart of an important peace deal after years of civil war. Also, Henry prepares to send his operative undercover, Jay deals with his tenuous marital situation, and Daisy makes a shocking discovery regarding Kevin.

Elizabeth is shocked when the Philippines' unconventional new president, Datu Andrada, makes a pass at her during their meeting to discuss his refusal to participate in an Asia-Pacific territory treaty. Also, Elizabeth asks Jay to look into Kevin Park's CIA connections, and Henry fears for his operative who is embedded in the religious cult when he goes radio silent.

Elizabeth’s landmark global climate treaty with more than 200 countries is jeopardized when China threatens to back out due to her meeting with an ailing Dalai Lama. Also, Henry worries about his undercover operative’s safety, and Jay is surprised when Abby serves him with a custody agreement for their daughter.

When a computer sting uncovers the possible mole in the CIA arms smuggling ring, Elizabeth’s questioning of the suspect makes her think that a larger, more dangerous force is behind the operation. Also, Henry worries that the doomsday cult is drugging his embedded operative, and Elizabeth and her State Department staff come up with an unorthodox approach to solving black rhino poaching in Namibia.

Elizabeth enlists the help of Hollywood star Ashley Whittaker to help sway the president of Kyrgyzstan to end human trafficking in his country, but the added attention could put an American captive at risk. Also, when Henry finds the bomb that’s being held by the doomsday cult, he uncovers information that they could be planning a deadlier attack.

When warring rebel groups threaten Elizabeth’s Somalian food relief efforts and kidnap an American aide there, she reluctantly considers asking a notorious Russian arms dealer for help. Also, Henry is blindsided when he is taken off the VFF doomsday cult case, and Alison and Stevie await their college acceptances.

As the U.S. hunts for the person believed to be behind the CIA arms smuggling case, Elizabeth and her team must work to save Jay when he’s kidnapped in Nice, France, during a fact-finding mission into the suspect. Also, Henry suspects the doomsday cult is planning an attack in Israel, and Jason dupes his parents into giving him money for an expensive calculator when he’s really using it to impress a girl.

As Elizabeth and President Dalton head to Rome for the G20 Conference, she is concerned for Henry’s safety when he is sent to Israel to intercept the doomsday cult’s bio-weapon before it is deployed. Also, Blake reveals a personal secret to his former colleagues that he meets at the conference, and Elizabeth goes behind Stevie’s back to ask Russell to get her off Harvard Law School’s waiting list.