After the death of her husband, Cassie Nightingale and her family find themselves caring for her ailing father-in-law. Moving in next door are the Radfords, Sam and Nick. Sam, the town's new doctor, has difficulty getting patients, as the town goes to Cassie's store for her more earthly herbal remedies.

Middleton's Heritage Festival gets everyone talking; Cassie is back to her bewitching ways as she welcomes a scared young woman to the Grey House but she realizes she's being followed.

Trouble is brewing after Cassie's mystery guest Ashley goes missing, and another pair of visitors to Middleton shake things up just in time for the town's annual heritage ball.

Cassie's mischievous cousin Abigail returns to Middleton, forcing Cassie to attempt tough love as Sam and Grace are swept up in Abigail's spell.

Cassie's magic can't keep her away from Abigail's scheming when the truth becomes too hard to hide and Abigail continues to stir the pot in Middleton.

Cassie tries to convince Sam to follow her intuition in order to help a young couple survive a blizzard.

A storm continues to threaten the lives of the people in Middleton and Cassie and Sam work together to help.

Cassie receives devastating news regarding the future of Bell, Book and Candle; the whole town comes together.

As Cassie's old friend John attempts to unearth their shared college memories, the Good Witch receives another visitor from her past when Ryan returns to Middleton seeking closure.