An explosion rips through the downstairs of Beth-H, changing lives there forever.

When an injured firefighter develops curious and frightening post-op symptoms, Mel and Jerry clash over how to proceed.

Griffin is forced to account for his actions when a patient dies while under his supervision.

Allen performs an extraordinarily rare and dangerous medical procedure, and Zoe’s mother turns up at Beth-H unexpectedly.

Exhilarated by her new romance with Cutler, Mel is uncharacteristically reckless in the operating room.

Cutler is drawn into a critical case with a husband and wife who are at odds over the treatment of her unexplained illness.

Allen works to diagnose a reclusive young woman’s illness, while Griffin begins to come apart at the seams.

Mel explores the significance of a literal and figurative broken heart, while Griffin embarks on a drug-fueled odyssey.

A clumsy attempt at addressing Griffin’s drug problem pushes him further down the spiral.

Mel does everything in her power to save a gravely wounded Sandy, while Griffin finally confronts the reality of his addiction.