Jackson discovers that Abraham is alive and stages a daring rescue to bring his friend home safely. Meanwhile, Jamie suspects that Reiden Global's pesticide is responsible for the lion attacks and convinces Mitch to help her. In Paris, a mysterious man approaches Chloe and asks her to accompany him.

Jamie contacts a fellow journalist in an attempt to expose the truth about Reiden’s involvement in the global animal problem. After realizing Delavenne works for Reiden, Mitch escapes with both the Mother Cell and his daughter’s medication. However, on their way to deliver the medication, Mitch and Abraham come face-to-face with a terrifying army of birds.

Jackson and the team make a final attempt to find a cure to the worldwide animal pandemic, but hit an obstacle that may be impenetrable.

Following a shift in violent animal behavior, the team attempt to rescue Jamie and secure the leopard that could hold the key to curing the animal crisis.

The discovery of a shocking mutation comes with potentially dire consequences for a member of the team.

Jackson faces the most difficult decision of his life. Also, Mitch reluctantly enlists help from his father, Max Morgan, to investigate the origin of the final set of triple helix animal bones,

Mitch and Jamie hatch a daring plan to undermine the Noah Objective once and for all, and the team reunites on the Island of Pangaea where the final pieces of the cure are put in place.

Ten years after the animals were cured but at the cost of sterilizing the human population, a new threat rises in the form of “the hybrids,” an army of unstoppable lab-made creatures focused on destroying mankind.

Jackson and Logan discover a link between the hybrid attacks that occur in Portland and New York; Mitch is interrogated by a woman claiming to be his daughter, Clementine; and a new development in Abraham’s research into the sterility crisis endangers his family.

Mitch seeks to rescue Clementine from her captors, and a glimpse into Jackson’s sister Abigail’s past reveals the origins of the hybrids.

The team races to stop the hybrids from breaching the barrier wall by shutting down the last beacon that draws them in.