The staff adjusts to the new normal of the pandemic. Dr. Choi, Dr. Lanik and April fight on the front lines. Dr. Halstead and Hannah face a troubling reality. Dr. Charles tries to clear the air with his daughter following recent developments.

Dr. Marcel and Dr. Manning lay everything on the line to assist a sick woman. Dr. Halstead faces an uphill battle in getting participants involved in his clinical trial. Dr. Choi clashes with a patient who demands absolute perfection of himself.

Will runs into trouble when one of his trial patients falls ill. His own stress and symptoms have Ethan struggling to get through the day.

Crockett deals with a patient who ends up having more in common with him than he thinks. Will and Ethan clash over a pregnant patient with an irregular heartbeat.

An auto accident sends Goodwin into a spiral as she tries to help a young boy and his mother. Natalie's secretive behavior begins to draw the attention of Dr. Marcel and Dr. Halstead.

Carol receives a second chance at life when a new heart becomes available. Ethan and Dean find themselves in hot water with an old patient. Will faces the consequences of the stolen trial medication.

Will Halstead returns to Med to help Goodwin with a secret investigation. Archer and Charles deal with twins who insist on being identical inside and out. Stevie and Dylan treat a young patient with sickle cell anemia.

Charles helps Dylan with a longtime patient who was recently diagnosed with schizophrenia. Stevie, Maggie and Vanessa investigate the legitimacy of a patient’s cancer diagnosis. Crockett is caught off-guard. Will pitches a new medical technology.

Crockett helps Dr. Blake replace a patient’s liver. Vanessa tries to prove herself. Will continues to pursue the truth about Cooper. Ethan gets closer to returning to life in the E.D.

In the aftermath of the Vas-COM scandal, Goodwin clashes with the hospital’s new compliance officer. Crockett and Blake try to save a patient who has a son with severe autism. A patient’s son lies to his father about his diagnosis.

Scott and Archer diagnose a pregnant woman with a serious infection. Maggie receives shocking news. Halstead and Charles question an elderly patient’s Alzheimer’s diagnosis. In an effort to help a patient, Marcel takes a risk.

Halstead helps a patient with long-haul COVID-19 symptoms. Taylor reflects on her dating life when she learns that a patient's daughter is having an arranged marriage.

Halstead and Asher work to save a surrogate's baby. Charles cares for a patient on a hunger strike. Choi and Archer help a patient with ties to Choi's late father. Scott and Maggie are stumped by a drunk patient who claims to be sober.

Halstead and Asher clash over a patient in need of a kidney transplant. Marcel faces a tough decision when Blake is in surgery. Choi and Archer treat the son of Med's general counsel. Med's family grows.

In the aftermath of Halstead's apartment fire, Marcel, Choi and Archer work together to try to save the survivors. Charles and Med's new fellow, Cuevas, help a paranoid patient.

When a subway train goes off the tracks, Marcel volunteers to help the victims. Taylor and Halstead must decide if they’re willing to risk their jobs to save a patient. Asher and Archer clash over a pregnant patient.

Med runs out of scrubs, forcing the staff to improvise. The life of Archer’s son is in danger. Marcel and Charles help a kidney transplant patient experiencing psychosis. Asher and Halstead grow closer.

Charles and Cuevas help an elderly patient and her developmentally disabled grandson. Halstead treats a swimmer with a heart condition. Marcel considers using the OR 2.0 for surgery.

A brutal storm rocks Chicago. Halstead encourages Dr. Grace Song to go against her own findings for the benefit of their patient. Asher rushes to the hospital to help Archer's pregnant patient. Maggie's concern for Ben consumes her.

Halstead and Cuevas struggle to diagnose a patient with a rare disorder. CFD and Med staff work to free a paranoid father trapped in the MRI suite. Tanaka-Reed gets an ego check.

The fate of the hospital rests on the vote of an incapacitated board member. Archer helps a mother with a rare stem cell disease while Asher treats the woman's pregnant daughter. Charles encounters a schizophrenic patient with a hearing impairment.

Shocking information threatens Jack Dayton's surgery and the future of OR 2.0. Archer goes rogue to save a patient in need. Maggie questions her future at Med.

When a commuter ship capsizes, the ED finds itself under water as the staff struggles to treat the influx of new patients and deal with bold new employees taking charge.

A familiar face returns to the ED. Ripley and Charles treat a woman with a rare disorder. Frost suspects that his patient's father is lying about his daughter's condition.

Ripley and Frost uncover shocking information that conflicts with their patient's DNR. Asher facilitates an unexpected reunion. The tension between Archer and Lenox comes to a head.

An army of surgeons prepares to separate conjoined twins. Asher reconnects with someone from her past. Archer treats a tyrannical boss with a heart problem.

Following the subway tunnel collapse, Ruzek and Kidd treat injured passengers and track down the missing offender. Archer and Frost perform a life-saving amputation.

The crossover starts on Chicago Fire S13E11 In the Trenches (I). It continues on Chicago P.D. S12E11 In the Trenches (III).

When her former patient returns to Med, Goodwin learns that time doesn't heal all wounds. Frost and Charles treat a patient struggling with his sexuality. Lenox and Abrams work to save a woman who has been in a coma for 20 years.

Maggie and Goodwin's friendship is tested as tensions rise during the nurses' union's negotiations with the hospital. Ripley and Archer treat a skateboarder struck by an emergency vehicle. Frost helps a young boy abandoned by his mother.

Goodwin is tasked with enforcing difficult cuts to hospital personnel. Charles' daughter is hospitalized after a car accident. A transplant patient makes a life-changing decision.